PEPITEM supports new bone and blood vessel growth in osteoporosis
While bones may appear solid and unchanging, they are a living tissue that is constantly being broken down and rebuilt in a process known as bone remodelling. Specialised cells (called osteoclasts) carefully remove old or damaged bone,
Looking inside the heart: how multiple chronic illnesses disrupt our cells
The aim of this study was to understand how having several ongoing health problems—what we refer to as multimorbidity—impacts the heart in people with cardiovascular disease, especially those undergoing heart surgery. Multimorbidity is becoming more common, particularly
Boosting chicken health with tea extract: a natural shield against stress
In modern poultry farming, chickens often face stressful conditions such as overcrowding, poor air quality, and contaminated feed. These conditions can lead to oxidative stress, a state where an excess of reactive oxygen species (ROS) overwhelms the
Boosting vaccine power: how injection site matters
A location of the body surface where a vaccine is administered might be just as important as the vaccine itself. Our research explores how injecting a vaccine at a specific acupoint called “Houhai” can lead to a
Anti-tumor IgE antibody: enhancing strength by stripping sugars
Antibody based therapeutics have emerged as a key player in the management of diseases including cancer with majority of monoclonal antibodies (mAbs) belonging to the IgG class. Recently, increasing efforts have been made to develop non-IgG class
UCLA researchers pioneer AI-based tissue staining to detect amyloid deposits without chemical stains or polarization microscopy
Los Angeles, CA – September 10, 2024 – Researchers at the University of California, Los Angeles (UCLA) have pioneered a groundbreaking approach in the imaging and detection of amyloid deposits in tissue samples. The innovative method leverages
Shutting down unwanted visitors: Please be quiet
Our cells respond to invading DNAs formed by viral infection in a variety of ways to suppress their ability to produce RNAs and proteins. One mechanism is to wrap the DNA with histones into a form of
Is multiple sclerosis triggered by immunological cross-recognition between an ancient virus and brain cell proteins?
Multiple sclerosis (MS) is an autoimmune disease where immune cells (T cells) and antibodies progressively damage the myelin sheath surrounding nerve cells leading to their loss of function. We have a reasonable understanding of the disease process
UCLA researchers develop high-sensitivity paper-based sensor for rapid cardiac diagnostics
A significant advancement for point-of-care medical diagnostics, a team of researchers from UCLA has introduced a deep learning-enhanced, paper-based vertical flow assay (VFA) capable of detecting cardiac troponin I (cTnI) with high sensitivity. The innovative assay holds
Unlocking new treatments for bone diseases: using PEPITEM to strengthen bones and prevent loss
Despite appearances, bones are a constantly changing organ in the body. Cells that produce new bone (named osteoblasts) and cells that break down bone (named osteoclasts) work in harmony to ensure that old bone is continuously replaced,
The Manikin Challenge: manikin-based simulation in the psychiatry clerkship
Psychiatry is a nuanced specialty that relies on body language and subtle nonverbal cues from patients. As such, when using simulation to teach medical students, standardized patients are considered the gold standard. Standardized patients are actors who
Does UV-B radiation modify gene expression?
Frequently the harsh environmental conditions, such as, high temperatures, low freezing conditions, high levels of PAR and UV-B sun radiation induce remarkable adaptive reactions in plants. These responses suggest that plants may possess genes associated with defence
Ferrate technology: an innovative solution for sustainable sewer and wastewater management
Sewers might be out of sight, but they play a huge role in shaping the well-being of a society. They quietly carry away all the wastewater from our homes, businesses, and factories, preventing harmful viruses, bacteria, and
Sleep abnormalities in different clinical stages of psychosis
Sleep abnormalities are commonly observed in individuals with schizophrenia and related psychotic disorders. Research shows that over half of people with these conditions have trouble sleeping. Poor sleep also often contributes to the development and worsening of
A compact high yield isotope enrichment system
Highly enriched isotopes such as 10B, 98Mo, and 100Mo are in great demand for the manufacturing of radioactive isotopes for medical diagnostic imaging studies and therapeutic applications. In order to produce useful quantities of the medical radioisotopes,
Late second trimester miscarriages
A second trimester miscarriage is the spontaneous loss of a pregnancy between 12 and 22 weeks of pregnancy. This is indeed a very sad experience to the parents. It has been said that a miscarriage may cause
Making Christmas trees under duress, or how cells regulate the production of ribosomal RNA
Some of the most enduring images for a molecular biologist are electron microscopy micrographs of the so-called “Christmas trees”, famously first observed by Oscar Miller from newt oocytes in 1969. These intriguing structures (Fig. 1A) capture the
Rabbits with mammary carcinomas as a model for comparative pathology and translational science in breast cancer research
Within a breeding colony of rabbits, the American pathologist Harry Greene (1904-1969) observed that mammary carcinomas were restricted to certain families. This is suggestive of a familiar predisposition as it occurs in human breast cancer. In rabbits,
Could mometasone furoate be a viable glucocorticoid with fewer metabolic adverse effects?
Glucocorticoids are medications widely used to treat inflammation and allergies, and in contexts of immunosuppression such as after transplants. They are well-established and safe. The problem is that, when used for a long time, or in high
Galectin-9: A new target for beating atherosclerosis?
Atherosclerosis is a chronic medical condition characterised by the accumulation of fat in the walls of blood vessels, which obstruct the normal flow of oxygen-rich blood and can have severe health consequences. Peripheral arterial disease (PAD) is
